They are used in a wide range of applications where they present helpful properties for example foaming, solubilisation, antistatic.

New to C&EN's ranking, Balchem is a specialist in choline chloride, which is used in animal feed—where it helps promote growth—As well as in human diet. The firm released PuraChol, a branded line of choline chloride products, final yr.

Three new firms joined the group: ChampionX, which was Ecolab's former oil-area chemical business; the choline chloride maker Balchem; as well as agricultural chemical firm American Vanguard, which has grown recently.

Note: Figures are for companies on the very best 50 list reporting capital and/or R&D expenditures. n/a means not offered.

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